• Nucleofill Strong
Nucleofill Strong
Nucleofill Strong

The synergy of 4 types of stimulation:
 

  • Skin regeneration
  • Cleansing effect on the cells by increasing circulation and removing free radicals
  • Deep moisturizing effect 
  • Firming and contouring

 

Nucleofill is the new line of natural polynucleotide-based bio-stimulating gels, with a high viscosity, for protecting and rejuvenating the skin.

The product contains high molecular weight polynucleotide chains whose biochemical peculiarities make it highly viscoelastic and capable of binding and orient in space a considerable amount of water molecules, which are primarily retained in the hydrophilic groups level of phosphorylated sugars of the individual nucleotides.
 
 
Moisturizing effect
 
The strong moisturizing ability is mainly due to the water retention capabilities of the hydrophilic groups of the phosphorylated sugars of the single nucleotides.  
 
An “electrostatic sponge” is able to guarantee cellular well-being by conferring deep hydration to tissues.
 
 
Free radical scavenger effect
 
The polymeric macromolecules are able to also play an immediate “scavenger” action against free radicals. 
 
This effect of this polynucleotide gel is possible thanks to the chemical structure capable of blocking free radicals in the nitrogenous ring. 
 
Moreover, the progressive degradation of polynucleotide molecules by enzymes present in the extracellular environment, free metabolites which, in turn, accentuate the protection activity against free radicals.
 
 
Biostimulating effect
 
The bio-stimulating effect is given both by the presence of nucleoside structures capable of activating cell membrane receptors and by metabolites that are produced by the enzymatic attack during the degradation process. A slow and continuous effect.
 
By promoting the metabolic activity of the fibroblastic cells, polynucleotides collaborate to reintegrate into the dermis various fundamental autologous components (glucoseaminoglycans, proteins, glycoproteins, fibrils, etc.) tending to maintain their physiological functionality.
 
 
Their repeated administration over time determines: 
 

  • – protracted isosmotic hydration of the dermal matrix 
  • – an anti-radical action 

 
Both of these effects combine to recreate in the dermal matrix the most favorable physiological conditions for the regeneration and metabolic activity of fibroblasts, with long-lasting biorevitalizing effects.
 
The maturation of fibroblasts in myofibroblasts and the production of collagen determines a strong specific lifting and revitalizing effect suitable for all skin types.

  • Skin laxity with poor circulation
  • Dehydrated skin
  • Skin submitted to oxidative stress
  • Stretch marks
  • Scars
  • For those who want firming and contouring, more definition.
  • Bio-stimulation and increase in collagen type 1.
 
It’s recommended to have 2 treatments with 2-4 weeks in between each session, in severe cases you can have up to 4 treatments with 2-4 weeks intervals.
 
 
Side effects:

  • Bruising may occur
  • Some swelling in the injection area 1-2 days

No other side effects have been reported.

Nucleofill: a specific mechanism of action for optimal bio revitalization.
 
Polynucleotides activate two types of membrane receptors in fibroblasts:
 

  • – Receptor CD39
  • – Receptor CD40

 
The activation of these receptors leads to two effects:

 

  • – Stimulation of type I collagen production
  • – Maturation of fibroblasts in myofibroblasts
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The synergy of 4 types of stimulation:
 

  • Skin regeneration
  • Cleansing effect on the cells by increasing circulation and removing free radicals
  • Deep moisturizing effect 
  • Firming and contouring

 

Nucleofill is the new line of natural polynucleotide-based bio-stimulating gels, with a high viscosity, for protecting and rejuvenating the skin.

The product contains high molecular weight polynucleotide chains whose biochemical peculiarities make it highly viscoelastic and capable of binding and orient in space a considerable amount of water molecules, which are primarily retained in the hydrophilic groups level of phosphorylated sugars of the individual nucleotides.
 
 
Moisturizing effect
 
The strong moisturizing ability is mainly due to the water retention capabilities of the hydrophilic groups of the phosphorylated sugars of the single nucleotides.  
 
An “electrostatic sponge” is able to guarantee cellular well-being by conferring deep hydration to tissues.
 
 
Free radical scavenger effect
 
The polymeric macromolecules are able to also play an immediate “scavenger” action against free radicals. 
 
This effect of this polynucleotide gel is possible thanks to the chemical structure capable of blocking free radicals in the nitrogenous ring. 
 
Moreover, the progressive degradation of polynucleotide molecules by enzymes present in the extracellular environment, free metabolites which, in turn, accentuate the protection activity against free radicals.
 
 
Biostimulating effect
 
The bio-stimulating effect is given both by the presence of nucleoside structures capable of activating cell membrane receptors and by metabolites that are produced by the enzymatic attack during the degradation process. A slow and continuous effect.
 
By promoting the metabolic activity of the fibroblastic cells, polynucleotides collaborate to reintegrate into the dermis various fundamental autologous components (glucoseaminoglycans, proteins, glycoproteins, fibrils, etc.) tending to maintain their physiological functionality.
 
 
Their repeated administration over time determines: 
 

  • – protracted isosmotic hydration of the dermal matrix 
  • – an anti-radical action 

 
Both of these effects combine to recreate in the dermal matrix the most favorable physiological conditions for the regeneration and metabolic activity of fibroblasts, with long-lasting biorevitalizing effects.
 
The maturation of fibroblasts in myofibroblasts and the production of collagen determines a strong specific lifting and revitalizing effect suitable for all skin types.

  • Skin laxity with poor circulation
  • Dehydrated skin
  • Skin submitted to oxidative stress
  • Stretch marks
  • Scars
  • For those who want firming and contouring, more definition.
  • Bio-stimulation and increase in collagen type 1.
 
It’s recommended to have 2 treatments with 2-4 weeks in between each session, in severe cases you can have up to 4 treatments with 2-4 weeks intervals.
 
 
Side effects:

  • Bruising may occur
  • Some swelling in the injection area 1-2 days

No other side effects have been reported.

Nucleofill: a specific mechanism of action for optimal bio revitalization.
 
Polynucleotides activate two types of membrane receptors in fibroblasts:
 

  • – Receptor CD39
  • – Receptor CD40

 
The activation of these receptors leads to two effects:

 

  • – Stimulation of type I collagen production
  • – Maturation of fibroblasts in myofibroblasts
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